What is 3-Hydroxyphenazepam
3-Hydroxyphenazepam is a potent benzodiazepine derivative that acts as an active metabolite of the drugs phenazepam and cinazepam. It features sedative, hypnotic, and anxiolytic properties, and it has occasionally been sold directly as a designer drug on online illicit markets.
3-Hydroxyphenazepam is a benzodiazepine with hypnotic, sedative, anxiolytic, and anticonvulsant properties. It is an active metabolite of phenazepam, as well as the active metabolite of the benzodiazepine prodrug cinazepam.
Relative to phenazepam, 3-hydroxyphenazepam has diminished myorelaxant properties, but is about equivalent in most other regards.
Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an EC50 value of 10.3 nM. It has been sold as a designer drug.
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