What is N-Acetyl-D-galactosamine
N-Acetyl-D-galactosamine (GalNAc) is an aldohexose (2-acetamido-2-deoxygalactose) in which the hydroxyl group at position 2 is replaced by a N-Acetyl group (Collins, 2006).
GalNAc forms a key part of both N- and O-linked glycoproteins, glycolipids, gangliosides, blood groups, glycosaminoglycans (chondroitin and dermatan sulfate) and human milk oligosaccharides.
The number of acetylgalactosamine residues attached to the IgA O-linked glycans of Crohn’sdisease patients is significantly decreased, and strongly correlated with clinical activity.
It is suggested that alterations of GalNAc attachment in IgA may be useful as a novel diagnostic and prognostic marker of Crohn’s disease (Inoue, 2012).
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