What is α-PVP Alpha-pyrrolidinopentiophenone Crystal (Flakka)
α-Pyrrolidinovalerophenone (α-PVP), also known as α-pyrrolidinopentiophenone , O-2387, β-keto-prolintane, prolintanone, or desmethylpyrovalerone, or colloquially as flakka or gravel, is a synthetic stimulant of the cathinone class developed in the 1960s that has been sold as a designer drug and often consumed for recreational reasons.
α-PVP is chemically related to pyrovalerone and is the ketone analog of prolintane.
α-PVP is used by a variety of different routes of administration, including oral, insufflation, injection, vaporization, sublingual, and rectal.
The dose range of α-PVP for therapeutic purposes was originally defined as 10 to 50 mg, with a most-suitable dose of 20 mg, whereas the recreational dose range is typically between 10 and 300 mg. The effects of α-PVP onset after 10 minutes, peak after 10 to 40 minutes, and last 2 to 3 hours.
The effects of α-PVP include cocaine-like psychostimulant effects, euphoria, elevated mood, alertness, pleasurable rush, feeling “sped up”, mania-like symptoms, enhanced energy, motivation and productivity, enhanced music enjoyment, mild sexual stimulation, insomnia, paranoia, hallucinations, and increased aggression and violence.
In emergency settings, commonly observed effects have included psychosis-like state, agitation, aggression, hallucinations, abnormal heart rate, and vomiting. It also produces sympathomimetic effects, such as increased heart rate and blood pressure.
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