What is 4-AcO-DET, 4-acetoxy-N,N-diethyltryptamine
4-AcO-DET, also known as 4-acetoxy-N,N-diethyltryptamine as well as ethacetin or ethylacybin, is a psychedelic tryptamine.
It is expected that 4-AcO-DET is quickly hydrolyzed into the free phenolic 4-HO-DET by serum esterases, but human studies concerning the metabolic fate of this drug are lacking.
Analogues of 4-AcO-DET include diethyltryptamine (DET), 4-HO-DET (ethocin), ethocybin (4-PO-DET), 4-AcO-DMT (psilacetin), 4-AcO-DPT, 4-AcO-MET, and 4-AcO-MPT, among others.
4-AcO-DET is orally active, and doses of 10 to 25 mg are common. Effects last 3 to 6 hours. The free base is also active when smoked in a dose range of 5 to 20 mg. Smoking 4-AcO-DET greatly speeds up the onset; peak effects are experienced within 10 minutes, and are usually over within 1 hour.
4-AcO-DET was first synthesized by Albert Hofmann and Franz Troxler at Sandoz in 1958.






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