What is Crack Cocaine
Crack cocaine, commonly known simply as crack, and also known as rock, is a free base form of the stimulant cocaine that can be smoked. Crack offers a short, intense high to smokers.
The Manual of Adolescent Substance Abuse Treatment calls it the most addictive form of cocaine.
Crack cocaine first saw widespread use as a recreational drug in primarily impoverished neighborhoods in New York City, Philadelphia, Baltimore, Washington, D.C., Los Angeles, San Francisco and Miami in late 1984 and 1985. This rapid increase in use and availability was named the “crack epidemic”, which began to wane in the 1990s.
The drug creates quick effects when smoked. Crack cocaine takes five to ten seconds before symptoms are shown. Short-term effects of the drug include euphoria, hyper-focus, sociability, cardiovascular hypertension, dilated pupils, hyperthermia, vertigo, tremors, and restlessness.
Repeated use can lead to respiratory failure, seizures, CNS depression, and cardiomyopathy. The drug also tends to cause users to develop paranoia, delusions of bugs under their skin, and in high doses, psychosis.
Pharmacologically, cocaine acts as a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI),producing reinforcing effects such as euphoria, increased alertness, concentration, libido, and reduced fatigue and appetite.
Cocaine has numerous adverse effects. Acute use can cause vasoconstriction, tachycardia, hypertension, hyperthermia, or seizures, while overdose may lead to stroke, heart attack, or sudden cardiac death.
It also produces a spectrum of psychiatric symptoms, including agitation, paranoia, anxiety, irritability, psychosis, hallucinations, delusions, violence, and suicidal or homicidal thinking.
Prenatal exposure poses risks to fetal development. Chronic use may result in cocaine dependence, withdrawal symptoms, neurotoxicity, and nasal damage, including cocaine-induced midline destructive lesions.
Coca cultivation and initial processing occur primarily in Latin America, especially in the Andes regions of Bolivia, Peru, and Colombia. Cultivation is expanding into Central America, including Honduras, Guatemala, and Belize.
Violence linked to the cocaine trade continues to affect Latin America and the Caribbean and is expanding into Western Europe, Asia, and Africa as transnational organized crime groups compete globally. Cocaine remains the world’s fastest-growing illicit drug market.
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Technical Data
CAS:[50-36-2]
Related CAS: 53-21-4 (hydrochloride)
Melting Point: 98 °C
Solubility: 1800 mg/L (at 22 °C)
SMILES: CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)OC(=O)C3=CC=CC=C3)C(=O)OC
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